23andMe

With the world’s largest database of more than ten million genotyped customers, 23andMe is at the forefront of using human genetics to advance biomedical research and transform healthcare. Join our growing research team in translating genetic discoveries into insights into molecular biology of human traits and diseases. As an Annotations Scientist at 23andMe, you will work closely with our Statistical Genetics and Computational Biology teams to source, curate, and implement databases for the analysis of genomic data in support of 23andMe’s drug target discovery and other research efforts.  Who We Are Since 2006, 23andMe’s mission has been to help people access, understand, and benefit from the human genome.  We are a group of passionate individuals pushing the boundaries of what’s possible to help turn genetic insight into better health and personal understanding. What You'll Do Identify, ingest and provide access to a comprehensive set of genomic and functional datasets. Develop and implement a strategy for how to use and deploy genomics and functional annotations data at 23andMe, in support of interpretation of human genetic variation. Develop tools and APIs for serving diverse genomics data types in a high-throughput and flexible manner. Follow genetics, functional genomics, bioinformatics literature and attend appropriate conferences to maintain awareness of desirable and state-of-the-art annotations and methods. Install, test, and deploy external tools to support curation, processing and high performance presentation of annotations to other researchers.  Design and implement in-house tools and APIs when third-party tools are insufficient. Develop, evaluate, and apply methods and test plans to assure data integrity and consistency. What You'll Bring Significant bioinformatics experience (at least three years) in a research setting , with a Ph.D. or M.S. in Bioinformatics, Computational Biology, Computer Science, Human Genetics, Molecular Biology or related field . Expertise with tools and methods for predicting functional consequences of genetic variants (VEP, snpEff, etc.), and underlying models and data sources. Proficiency with major bioinformatics resources ( Ensembl suite, UCSC Genome Browser suite, TCGA, gnomAD/ExAC, GTEx, etc.) and in-depth understanding of at least one of these ecosystems . Hands-on experience with relational databases (MySQL, Postgres, etc.) and fluency with at least one advanced data storage and retrieval technologies (such as Amazon Redshift, Hadoop, HDFS, etc.).  Fluency in R/Python and occasionally other languages as needed for data processing and API development. Experience with workflow development using shell scripting and standard GNU tools. Experience working in cross-functional teams.   Pluses Understanding of gene expression and gene regulation datasets, such as e/p/mQTLs, chromatin marks, etc. Experience with cloud computing with AWS. Ability to engineer and tune large scale databases for performant read and write access of large datasets. About Us 23andMe, Inc. is the leading consumer genetics and research company. Our mission is to help people access, understand and benefit from the human genome. The company was named by MIT Technology Review to its “50 Smartest Companies, 2017” list, and named one of Fast Company’s “25 Brands That Matter Now, 2017”. 23andMe has over 5 million customers worldwide, with ~85 percent of customers consented to participate in research. 23andMe is located in Sunnyvale, CA. More information is available at  www.23andMe.com . At 23andMe we value a diverse, inclusive workforce and we provide equal employment opportunity for all applicants and employees. All qualified applicants for employment will be considered without regard to an individual’s race, color, sex, gender identity, gender expression, religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. 23andMe will reasonably accommodate qualified individuals with disabilities to the extent required by applicable law. Please note: 23andMe does not accept agency resumes and we are not responsible for any fees related to unsolicited resumes. Thank you.

Who we are 23andMe, the leading consumer genetics company, has accumulated a wealth of genetic and phenotypic information from research participants committed to improving human health through advances in genomics. Our Therapeutics team based in South San Francisco uses this unparalleled dataset to discover and develop novel treatments for patients with serious unmet needs. Biological interpretation of genetic signals available to 23andMe requires computational methods to analyze high-throughput functional data, development of tools that integrate genetics and functional genomics to drive target discovery, and summarizing the results in ways that enable efficient decision making. More information about our Therapeutics team is available at  https://therapeutics.23andme.com/ . Who you are We are looking for a quantitative scientist with extensive experience in computational biology and bioinformatics. Ideal candidates will have significant experience in working with large genomic datasets and developing robust software tools that drive discovery and interpretation. Our team is very collaborative, and the ability to communicate ideas and results to other scientists is key. What you’ll bring Ph.D. -- or M.S. with at least 5 years of working experience in a research setting -- in Computational Biology, Computer Science, Bioinformatics, Statistics or a related field Hands-on experience working with very large genomic datasets Strong programming skills in (preferably) R or python, and demonstrated ability to write R packages / python libraries for broad use Experience working with SQL and relational databases Extensive experience in writing robust code in a shared development environment Experience in deploying internally developed tools in a production environment Ability to work in a dynamic team oriented environment Good communication skills and experience communicating software or database design to colleagues Pluses Contribution to an open source project, especially in R Familiarity with tools for processing WGS, RNA-seq, ATAC-seq, ChIP-seq or similar Experience in summarizing data to help drive interpretation and decision making Note:  Job title will be commensurate with experience and academic credentials About Us 23andMe, Inc. is the leading consumer genetics and research company. Our mission is to help people access, understand and benefit from the human genome. The company was named by MIT Technology Review to its “50 Smartest Companies, 2017” list, and named one of Fast Company’s “25 Brands That Matter Now, 2017”. 23andMe has over 10 million customers worldwide, with ~80 percent of customers consented to participate in research. More information is available at  www.23andMe.com . At 23andMe, we value a diverse, inclusive workforce and we provide equal employment opportunity for all applicants and employees. All qualified applicants for employment will be considered without regard to an individual’s race, color, sex, gender identity, gender expression, religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws.  If you are unable to submit your application because of incompatible assistive technology or a disability, please contact us at accommodations-ext@23andme.com . 23andMe will reasonably accommodate qualified individuals with disabilities to the extent required by applicable law. Please note: 23andMe does not accept agency resumes and we are not responsible for any fees related to unsolicited resumes. Thank you.

Who we are Since 2006, 23andMe’s mission has been to help people access, understand, and benefit from the human genome. We are a group of passionate individuals pushing the boundaries of what’s possible to help turn genetic insight into better health and personal understanding. Our Therapeutics team, which was established more than five years ago, has been actively identifying novel drug targets using 23andMe’s unparalleled database and developing a portfolio across several therapeutic areas, including oncology and cardiovascular and metabolic disease.  More information about our Therapeutics team is available at  https://therapeutics.23andme.com/ . We are looking for a quantitative scientist with extensive experience in computational biology. Ideal candidates will have demonstrated experience conducting creative and independent research analyzing a broad range of public or internally generated genomic datasets, with an emphasis on understanding the underlying biology. Join our collaborative, cross-functional research team focused on discovery of novel therapeutic targets and their development in our laboratories! What you’ll do Biological interpretation of genetic signals available to 23andMe, which requires computational methods to analyze high-throughput functional data Development of tools and reports that integrate genetics and functional genomics to drive target discovery  and summarizing the results in ways that enable efficient decision making Extend existing target discovery efforts to incorporate additional data types and novel analysis methods; work toward identifying clinically relevant disease subtypes and associated therapeutic targets; and contribute to on-going therapeutic development programs Communicate ideas and results to other scientists What you’ll bring Ph.D. in Computational Biology, Bioinformatics, Biostatistics, Genetics or a related field Knowledge of biology in at least one disease-relevant area (e.g., cardiovascular diseases, oncology, immunology, etc.) Hands-on experience in analysis of RNA-seq or microarrays, and other large scale omics datasets Fluency with tools and methods for processing functional sequencing data (RNA-seq, ATAC-seq, ChIP-seq or similar) Strong quantitative skills and a background in statistical data analysis or machine learning Experience in writing robust code in R or python Exceptional communication skills, with an ability to convey complex computational results to colleagues from a wide range of life sciences backgrounds Ability to work in a dynamic team-oriented environment Pluses Industry experience in pharmaceuticals or biotechnology Expertise in genetics and/or  fine mapping of genetic association signals Extensive experience in writing robust code in a shared development environment Note:  Job title will be commensurate with experience and academic credentials About Us 23andMe, Inc. is the leading consumer genetics and research company. Founded in 2006, the mission of the company is to help people access, understand, and benefit from the human genome. The company was named by Glassdoor as one of the Best Places to Work in 2019, MIT Technology Review to its “50 Smartest Companies, 2017” list, and named one of Fast Company’s “25 Brands That Matter Now, 2017”. 23andMe has millions of customers worldwide, with more than 80 percent of customers consented to participate in research. 23andMe, Inc. is located in Sunnyvale, CA. More information is available at  www.23andMe.com . At 23andMe, we value a diverse, inclusive workforce and we provide equal employment opportunity for all applicants and employees. All qualified applicants for employment will be considered without regard to an individual’s race, color, sex, gender identity, gender expression, religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws.  If you are unable to submit your application because of incompatible assistive technology or a disability, please contact us at accomodations-ext@23andme.com . 23andMe will reasonably accommodate qualified individuals with disabilities to the extent required by applicable law. Please note: 23andMe does not accept agency resumes and we are not responsible for any fees related to unsolicited resumes. Thank you.